discoveryexpress™

Discovery of biomarkers and drug targets

discoveryexpress™ includes a suite of methods and platforms for biomarker and drug target discovery. NextGen Sciences will work with you to develop a customized plan to meet the objectives and timelines of your project.

The core of these services are techniques for determining the relative quantitation of protein abundance in different samples or sample groups. NextGen Sciences has a wealth of expertise in analytical protein chemistry and can provide additional services as appropriate to your needs.

• Quantitating protein abundance
• Protein Identification
• Analysis of post-translational modifications
• De-novo sequencing
• Mapping protein complexes
• Proteome mapping

NextGen Sciences can assist you in the selection of the discovery platform that best meet the needs of your project. The following are key considerations in the choice of discovery platform:

• Biological system: Is the genome sequenced? How are samples collected & processed?
• Sample availability: The number of samples available, over how many groups (e.g. diseased & normal)?
• Sensitivity / Proteome Coverage: How 'deep' into the proteome to probe for biomarker?
• Confidence / Statistical rigor: How the discoveries will be confirmed?
• Identification: Identification of all proteins detected or only differentially expressed proteins?

NextGen Sciences has experience with the following sample types:

• Biofluids
• Tissues
• Cells and conditioned media
• Formalin-Fixed, Paraffin-Embedded (FFPE) Tissue
• Proximal fluids
• Plants